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High Frequency of <i>TP53</i> Mutation in <i>BRCA1</i> and Sporadic Basal-like Carcinomas but not in <i>BRCA1</i> Luminal Breast Tumors

15 Jan 2009

Abstract excerpt

Breast tumors with a germ-line mutation of BRCA1 (BRCA1 tumors) and basal-like carcinoma (BLC) are associated with a high rate of TP53 mutation. Because BRCA1 tumors frequently display a basal-like phenotype, this study was designed to determine whether TP53 mutations are correlated with the hereditary BRCA1 mutated status or the particular phenotype of these tumors. The TP53 gene status was first investigated in...

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PMID: 19147582
DOI: 10.1158/0008-5472.can-08-1560

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