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Article

Clinicopathologic features of CDK6 translocation-associated B-cell lymphoproliferative disorders.

The American journal of surgical pathology - 1 May 2009

Chen Dong, Law Mark E, Theis Jason D, Gamez Jeffrey D, Caron Lynn B, Vrana Julie A, Dogan Ahmet

Abstract excerpt

Cyclin-dependent protein kinase 6 (CDK6), in cooperation with cyclin Ds, drives cell cycle progression from G1 to S phase through phosphorylation and subsequent inactivation of retinoblastoma 1 protein. Alteration of this pathway results in both nonhematologic and hematologic malignancies, which include a small subset of B-cell lymphoproliferative disorders (BLPDs). We identified 5 cases of BLPD that carried CDK6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cyclin-Dependent Kinase Inhibitor p27

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Source

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Identifiers

PMID: 19145199
DOI: 10.1097/PAS.0b013e3181934244
PMCID: PMC2674112

Genes

CDK6

Provenance

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