Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities.

doi:10.1111/bjh.17141

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Article

Clinical and biological features of B-cell neoplasms with CDK6 translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and TP53 abnormalities.

British journal of haematology - 1 Apr 2021

Gailllard Baptiste, Cornillet-Lefebvre Pascale, Le Quoc-Hung, Maloum Karim, Pannetier Mélanie, Lecoq-Lafon Carinne, Grange Béatrice, Jondreville Ludovic, Michaux Lucienne, Nadal Nathalie, Ittel Antoine, Luquet Isabelle, Struski Stéphanie, Lefebvre Christine, Gaillard Jean-Baptiste, Lafage-Pochitaloff Marina, Balducci Estelle, Penther Dominique, Barin Carole, Collonge-Rame Marie Agnès, Jimenez-Poquet Mélanie, Richebourg Steven, Lemaire Pierre, Defasque Sabine, Radford-Weiss Isabelle, Bidet Audrey, Susin Santos A, Nguyen-Khac Florence, Chapiro Elise

Abstract excerpt

A translocation involving the cyclin-dependent kinase 6 (CDK6) gene [t(CDK6)] is a rare but recurrent abnormality in B-cell neoplasms. To further characterise this aberration, we studied 57 cases; the largest series reported to date. Fluorescence in situ hybridisation analysis confirmed the involvement of CDK6 in all cases, including t(2;7)(p11;q21) immunoglobulin kappa locus (IGK)/CDK6 (n = 51), t(7;14)(q21;q32)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD5 Antigens

Share to Cyclin-Dependent Kinase 6

Share to Immunoglobulin Heavy Chains

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, B-Cell, Marginal Zone

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Share to Translocation, Genetic

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Identifiers

PMID: 33314017
DOI: 10.1111/bjh.17141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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