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Article

Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase.

Pflugers Archiv : European journal of physiology - 1 Jul 2009

Missan Sergey, Qi Jiansong, Crack Julie, McDonald Terence F, Linsdell Paul

Abstract excerpt

The objective of the study was to investigate the role of tyrosine phosphorylation in the regulation of KCNQ1/KCNE1 channels. Large whole-cell time- and voltage-dependent K(+) currents were present in human embryonic kidney 293 cells cotransfected with human KCNQ1 and KCNE1 but not in control nontransfected cells. The time- and voltage-dependent current had biophysical properties typical of cardiac KCNQ1/KCNE1...

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Source

Identifiers

PMID: 19139916
DOI: 10.1007/s00424-008-0634-y

Genes

KCNQ1
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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