Article
The human P(k) histo-blood group antigen provides protection against HIV-1 infection.
Blood - 14 May 2009
Lund Nicole, Olsson Martin L, Ramkumar Stephanie, Sakac Darinka, Yahalom Vered, Levene Cyril, Hellberg Asa, Ma Xue-Zhong, Binnington Beth, Jung Daniel, Lingwood Clifford A, Branch Donald R
Abstract excerpt
Several human histo-blood groups are glycosphingolipids, including P/P1/P(k). Glycosphingolipids are implicated in HIV-host-cell-fusion and some bind to HIV-gp120 in vitro. Based on our previous studies on Fabry disease, where P(k) accumulates and reduces infection, and a soluble P(k) analog that inhibits infection, we investigated cell surface-expressed P(k) in HIV infection. HIV-1 infection of peripheral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.