Article
Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.
The Journal of biological chemistry - 2 Jun 2000
Steffensen R, Carlier K, Wiels J, Levery S B, Stroud M, Cedergren B, Nilsson Sojka B, Bennett E P, Jersild C, Clausen H
Abstract excerpt
The molecular genetic basis of the P histo-blood group system has eluded characterization despite extensive studies of the biosynthesis of the P(1), P, and P(k) glycolipids. The main controversy has been whether a single or two distinct UDP-Gal:Galbeta1-R 4-alpha-galactosyltransferases catalyze the syntheses of the structurally related P(1) and P(k) antigens. The P(1) polymorphism is linked to 22q11.3-ter. Data...
Topics
- Amino Acid Sequence
- Base Sequence
- Carbohydrate Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 22
- Cloning, Molecular
- Galactosyltransferases
- Homozygote
- Humans
- Molecular Sequence Data
- Mutation, Missense
- P Blood-Group System