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Article

Limited genetic variation in the Plasmodium falciparum heme detoxification protein (HDP).

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2009

Vinayak Sumiti, Rathore Dharmendar, Kariuki Simon, Slutsker Laurence, Shi Ya Ping, Villegas Leopoldo, Escalante Ananias A, Udhayakumar Venkatachalam

Abstract excerpt

Malaria parasites infecting host red blood cells degrade hemoglobin by detoxifying heme into hemozoin. This conversion of heme to hemozoin is performed by a potent protein called heme detoxification protein (HDP), making HDP an attractive target for antimalarial drug development. We studied the genetic variation in Plasmodium falciparum HDP and also investigated if HDP due to its involvement in the heme...

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Identifiers

PMID: 19135554
DOI: 10.1016/j.meegid.2008.12.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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