Article
Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes.
Development (Cambridge, England) - 1 Sept 2006
Yang Chao-Tsung, Johnson Stephen L
Abstract excerpt
We developed a method to efficiently ablate a single cell type, the zebrafish melanocyte, and study the mechanisms of its regeneration. We found that a small molecule, (2-morpholinobutyl)-4-thiophenol (MoTP), specifically ablates zebrafish larval melanocytes or melanoblasts, and that this melanocytotoxicity is dependent on tyrosinase activity, which presumably converts MoTP to cytotoxic quinone species. Following...
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