Article
Functional specific roles of H-ras and N-ras. A proteomic approach using knockout cell lines.
Electrophoresis - 1 May 2012
Ferreira Laura, Fuentes-Calvo Isabel, Muñoz-Félix José M, Muñiz-Martín Carmen, Sánchez-Juanes Fernando, Raposo César, González-Buitrago José M, López-Novoa José M, Martínez-Salgado Carlos
Abstract excerpt
Ras small GTPases function as transducers of extracellular signals regulating cell survival, growth and differentiation. There are three major ras isoforms: H-, N- and K-Ras. To improve the understanding of H- and N-Ras protein signalling networks, we compared total proteome changes in mouse embryonic fibroblasts knock out for H-ras and/or N-ras, using proteomics tools combining 2DE, semi-quantitative image...
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