Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene.

Genome biology and evolution - 27 Oct 2014

Ottolini Barbara, Hornsby Michael J, Abujaber Razan, MacArthur Jacqueline A L, Badge Richard M, Schwarzacher Trude, Albertson Donna G, Bevins Charles L, Solnick Jay V, Hollox Edward J

Abstract excerpt

β-defensins are a family of important peptides of innate immunity, involved in host defense, immunomodulation, reproduction, and pigmentation. Genes encoding β-defensins show evidence of birth-and-death evolution, adaptation by amino acid sequence changes, and extensive copy number variation (CNV) within humans and other species. The role of CNV in the adaptation of β-defensins to new functions remains unclear,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to beta-Defensins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Evolution, Molecular

Share to Macaca mulatta

Share to Mutation

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25349268
DOI: 10.1093/gbe/evu236
PMCID: PMC4255768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of convergent evolution in humans and macaques supports an adaptive role for copy number variation of the β-defensin-2 gene.PMID 25349268Read ↗

A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East AsiaSemantic proximity Read ↗

β-Defensin gene copy number variation in cattleSemantic proximity Read ↗

β-defensin gene copy number variation in cattleSemantic proximity Read ↗

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility.Semantic proximity Read ↗

Copy number variation of beta-defensins and relevance to disease.Semantic proximity Read ↗

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.Semantic proximity Read ↗

An atlas of CNV maps in cattle, goat and sheep.Semantic proximity Read ↗

Origins and long-term patterns of copy-number variation in rhesus macaquesSemantic proximity Read ↗

Assessment of copy number variants in three Brazilian locally adapted cattle breeds using whole-genome re-sequencing data.Semantic proximity Read ↗

Origins and Long-Term Patterns of Copy-Number Variation in Rhesus Macaques.Semantic proximity Read ↗

Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.Semantic proximity Read ↗

The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.