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Article

Phosphate regulates osteopontin gene transcription.

Journal of dental research - 1 Jan 2009

Fatherazi S, Matsa-Dunn D, Foster B L, Rutherford R B, Somerman M J, Presland R B

Abstract excerpt

Extracellular inorganic phosphate (ePi) is a key regulator of cementoblast behavior, both in vivo and in vitro, and results in a marked increase in osteopontin expression in vitro. To examine the molecular mechanisms involved in ePi induction of osteopontin gene expression, we transfected a series of osteopontin promoter-luciferase constructs into OCCM-30 cementoblasts. Our results demonstrate that ePi can...

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Identifiers

PMID: 19131315
DOI: 10.1177/0022034508328072
PMCID: PMC3128439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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