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Article

Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression.

The Journal of biological chemistry - 30 Mar 2001

Wan M, Shi X, Feng X, Cao X

Abstract excerpt

Osteoprotegerin (OPG), an osteoblast-secreted decoy receptor, specifically binds to osteoclast differentiation factor and inhibits osteoclast maturation. Members of the transforming growth factor-beta superfamily including bone morphogenetic proteins (BMPs) stimulate OPG mRNA expression. In this study, we have characterized the transcription mechanism of BMP-induced OPG gene expression. Transfection of Smad1 and...

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Source

Identifiers

PMID: 11139569
DOI: 10.1074/jbc.M006918200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression.PMID 11139569Read ↗

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