Article
Differential expression of SMAD3 transcripts is not regulated by cis-acting genetic elements but has a gender specificity.
Genes and immunity - 1 Mar 2009
Busque L, Belisle C, Provost S, Giroux M, Perreault C
Abstract excerpt
As a key component of the transforming growth factor-beta (TGF-beta) pathway, SMAD3 plays an essential role in development and maintenance of self-tolerance. Furthermore, a recent study based on gene-expression profiling in donors of allogeneic hematopoietic cell grafts revealed that the level of expression of several components of the TGF-beta pathway can predict the occurrence of graft-versus-host disease...
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