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Article

Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases.

PloS one - 1 Jan 2015

Li Fei-Feng, Zhou Jing, Zhao Dan-Dan, Yan Peng, Li Xia, Han Ying, Li Xian-Shu, Wang Gui-Yu, Yu Kai-Jiang, Liu Shu-Lin

Abstract excerpt

BACKGROUND: Nodal/TGF signaling pathway has an important effect at early stages of differentiation of human embryonic stem cells in directing them to develop into different embryonic lineages. SMAD3 is a key intracellular messenger regulating factor in the Nodal/TGF signaling pathway, playing important roles in embryonic and, particularly, cardiovascular system development. The aim of this work was to find...

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Source

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Identifiers

PMID: 26110764
DOI: 10.1371/journal.pone.0131542
PMCID: PMC4482402

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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