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Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing

15 Dec 2001

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is an oncogene and a critical regulator of multiple cell-fate decisions, including myeloid cell differentiation. Two isoforms of STAT3 have been identified: alpha (p92) and beta (p83). These differ structurally in their C-terminal transactivation domains, resulting in distinct functional activities. The cis genetic elements that regulate the ratio of...

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PMID: 11739197
DOI: 10.1182/blood.v98.13.3853

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