A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North American travelers to Mexico.

doi:10.1086/596319

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A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North American travelers to Mexico.

The Journal of infectious diseases - 15 Feb 2009

Mohamed Jamal A, DuPont Herbert L, Jiang Zhi-Dong, Flores Jose, Carlin Lily G, Belkind-Gerson Jaime, Martinez-Sandoval Francisco G, Guo Dongchuan, White A Clinton, Okhuysen Pablo C

Abstract excerpt

BACKGROUND: Osteoprotegerin (OPG), an immunoregulatory member of the TNF receptor superfamily, is expressed in inflamed intestinal mucosa. We investigated whether OPG is produced by intestinal epithelial cells and tested the hypothesis that single-nucleotide polymorphisms (SNPs) in the gene encoding OPG (TNFRSF11B) are associated with traveler's diarrhea (TD) among North American travelers to Mexico. METHODS: OPG...

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PMID: 19128145
DOI: 10.1086/596319
PMCID: PMC2742228

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