Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes.

Acta diabetologica - 1 Dec 2014

Biscetti Federico, Porreca Carlo Filippo, Bertucci Flavio, Straface Giuseppe, Santoliquido Angelo, Tondi Paolo, Angelini Flavia, Pitocco Dario, Santoro Luca, Gasbarrini Antonio, Landolfi Raffaele, Flex Andrea

Abstract excerpt

AIMS: Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arterial Occlusive Diseases
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Diabetic Angiopathies

Share to Extremities

Share to Genetic Association Studies

Share to Ischemia

Share to Osteoprotegerin

Source

Identifiers

PMID: 25323324
DOI: 10.1007/s00592-014-0664-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes.PMID 25323324Read ↗

Association between TNFRSF11B gene polymorphisms and history of ischemic stroke in Italian diabetic patients.Semantic proximity Read ↗

Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.Semantic proximity Read ↗

Osteoprotegerin gene rs2073617 and rs3134069 polymorphisms in type 2 diabetes patients and sex‑specific rs2073618 polymorphism as a risk factor for diabetic foot.Semantic proximity Read ↗

Associations of osteoprotegerin (OPG) TNFRSF11B gene polymorphisms with risk of fractures in older adult populations: meta-analysis of genetic and genome-wide association studies.Semantic proximity Read ↗

Gene Polymorphisms in the RANKL/RANK/OPG Pathway Are Associated with Type 2 Diabetes Mellitus in Southern Han Chinese Women.Semantic proximity Read ↗

A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men.Semantic proximity Read ↗

Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia.Semantic proximity Read ↗

Susceptibility to Paget's disease of bone is influenced by a common polymorphic variant of osteoprotegerin.Semantic proximity Read ↗

Genetic Polymorphisms and the Risk of Diabetic Foot: A Systematic Review and Meta-Analyses.Semantic proximity Read ↗

Relationships of OPG Genetic Polymorphisms with Susceptibility to Cardiovascular Disease: A Meta-Analysis.Semantic proximity Read ↗

TNFRSF11B polymorphisms predict poor outcome after large artery atherosclerosis stroke.Semantic proximity Read ↗

Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.