Article
A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Apr 2007
Mohamed Jamal A, DuPont Herbert L, Jiang Zhi Dong, Belkind-Gerson Jaime, Figueroa Jose Flores, Armitige Lisa Y, Tsai An, Nair Parvathy, Martinez-Sandoval Francisco J, Guo Dong-chuan, Hayes Patricia, Okhuysen Pablo C
Abstract excerpt
BACKGROUND: Diarrhea affects 40%-60% of travelers from industrialized nations who visit developing countries and is due to bacterial, viral, and parasitic agents. Lactoferrin is bactericidal to enteric pathogens, modulates the intestinal immune response, and is excreted in stool in response to infection with intestinal organisms. We investigated the impact that selected single-nucleotide polymorphisms (SNPs) in...
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