Article
Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.
Biochemical and biophysical research communications - 13 Feb 2009
Kamagata Eiichiro, Kudo Takashi, Kimura Ryo, Tanimukai Hitoshi, Morihara Takashi, Sadik Md Golam, Kamino Kouzin, Takeda Masatoshi
Abstract excerpt
Late-onset Alzheimer's disease (LOAD) is significantly associated with a single nucleotide polymorphism located in the dynamin (DNM) 2 gene, especially in non-carriers of the apolipoprotein E-epsilon4 allele. In this study we used real-time PCR to show that DNM2 mRNA is significantly reduced in the cortex of AD brains and in the peripheral blood of dementia patients. Neuroblastoma cells transfected with a...
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