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Article

Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.

Journal of human genetics - 1 Jan 2008

Aidaralieva Nuripa Jenishbekovna, Kamino Kouzin, Kimura Ryo, Yamamoto Mitsuko, Morihara Takeshi, Kazui Hiroaki, Hashimoto Ryota, Tanaka Toshihisa, Kudo Takashi, Kida Tomoyuki, Okuda Jun-Ichiro, Uema Takeshi, Yamagata Hidehisa, Miki Tetsuro, Akatsu Hiroyasu, Kosaka Kenji, Takeda Masatoshi

Abstract excerpt

Alzheimer disease (AD) is characterized by progressive cognitive decline caused by synaptic dysfunction and neurodegeneration in the brain, and late-onset AD (LOAD), genetically classified as a polygenetic disease, is the major form of dementia in the elderly. It has been shown that beta amyloid, deposited in the AD brain, interacts with dynamin 1 and that the dynamin 2 (DNM2) gene homologous to the dynamin 1...

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Source

Identifiers

PMID: 18236001
DOI: 10.1007/s10038-008-0251-9

Genes

DNM2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.PMID 18236001Read ↗

[Genetic risk factor of Alzheimer's disease].Semantic proximity Read ↗

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Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.Semantic proximity Read ↗

Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.Semantic proximity Read ↗

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