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Article

Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease.

Neurobiology of disease - 1 Mar 2003

Yao Pamela J, Zhu Min, Pyun Eunice I, Brooks Andrew I, Therianos Stavros, Meyers Victoria E, Coleman Paul D

Abstract excerpt

Loss of synapses correlates with cognitive decline in Alzheimer's disease (AD). However, molecular mechanisms underlying the synaptic dysfunction and loss are not well understood. In this study, microarray analysis of brain tissues from five AD cases revealed a reduced expression of a group of related genes, all of which are involved in synaptic vesicle (SV) trafficking. By contrast, several synaptic genes with...

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Identifiers

PMID: 12667465
DOI: 10.1016/s0969-9961(02)00009-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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