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Article

Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese.

Endocrine journal - 1 Jan 2009

Kuroda Eiji, Horikawa Yukio, Enya Mayumi, Oda Naohisa, Suzuki Eiji, Iizuka Katsumi, Takeda Jun

Abstract excerpt

Genetic analysis of the KLF11 gene revealed two rare variants, A347S and T220M, segregating in families with early-onset type 2 diabetes, and one frequent polymorphic Q62R variant significantly associated with type 2 diabetes in Northern Europeans. Furthermore, it has been reported that over-expression of KLF11 has a deleterious effect on insulin promoter activity. Thus, an altered expression level of KLF11 may...

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Source

Identifiers

PMID: 19122346
DOI: 10.1507/endocrj.k08e-302

Genes

KLF11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese.PMID 19122346Read ↗

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