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The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.

Diabetes - 1 Dec 2006

Florez Jose C, Saxena Richa, Winckler Wendy, Burtt Noël P, Almgren Peter, Bengtsson Boström Kristina, Tuomi Tiinamaija, Gaudet Daniel, Ardlie Kristin G, Daly Mark J, Altshuler David, Hirschhorn Joel N, Groop Leif

Abstract excerpt

Krüppel-like factor 11 is a pancreatic transcription factor whose activity induces the insulin gene. A common glutamine-to-arginine change at codon 62 (Q62R) in its gene KLF11 has been recently associated with type 2 diabetes in two independent samples. Q62R and two other rare missense variants (A347S and T220M) were also shown to affect the function of KLF11 in vitro, and insulin levels were lower in carriers of...

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Identifiers

PMID: 17130512
DOI: 10.2337/db06-0867

Genes

KLF11

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.PMID 17130512Read ↗

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