Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.

Diabetologia - 1 Jul 2007

Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel M D, Bretzel R G, Seufert J, Päth G

Abstract excerpt

AIMS/HYPOTHESIS: The Krüppel-like factor 11 (KLF11; TIEG2), a pancreas-enriched Sp1-like transcription factor, is a known negative regulator of pancreatic exocrine cell growth. A recent study indicated KLF11-induced activation of the human proinsulin promoter (hInsP). MATERIALS AND METHODS: We investigated the functional role of KLF11 in pancreatic beta cells. RESULTS: Endogenous KLF11 mRNA expression was found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucose

Share to Insulin

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Proinsulin

Share to Sp1 Transcription Factor

Source

Identifiers

PMID: 17479246
DOI: 10.1007/s00125-007-0667-3

Genes

KLF11
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.PMID 17479246Read ↗

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell functionSemantic proximity Read ↗

Autoregulation and Maturity Onset Diabetes of the Young Transcription Factors Control the Human PAX4 PromoterSemantic proximity Read ↗

Revealing transcription factors during human pancreatic β cell developmentSemantic proximity Read ↗

Identification of a novel PDX-1 binding site in the human insulin gene enhancer.Semantic proximity Read ↗

Sp/Krüppel-like transcription factors are essential for the expression of mitochondrial glycerol phosphate dehydrogenase promoter B.Semantic proximity Read ↗

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.Semantic proximity Read ↗

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured isletsSemantic proximity Read ↗

Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1.Semantic proximity Read ↗

Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese.Semantic proximity Read ↗

Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor.Semantic proximity Read ↗

Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factorSemantic proximity Read ↗

Positive and negative regulation of the human insulin gene by multiple trans-acting factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.