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Article

Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure.

Drug metabolism and pharmacokinetics - 1 Jan 2008

Tsujimoto Masayuki, Dan Yukihiko, Hirata Sumio, Ohtani Hisakazu, Sawada Yasufumi

Abstract excerpt

Digoxin (DX) is mainly excreted unchanged in the urine. In patients undergoing hemodialysis (HD patients), the relative contribution of hepatic elimination is increased. DX is a substrate of OATP1B3 (SLCO1B3), expressed on the sinusoidal membranes of hepatocytes in humans. Therefore, we investigated the relationship between SLCO1B3 gene polymorphisms and the value of trough concentration-to-dose ratio (C/D ratio)...

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Share to Digoxin
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Mutagenesis, Insertional

Share to Organic Anion Transporters, Sodium-Independent

Share to Polymorphism, Genetic

Share to Renal Insufficiency

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Source

Identifiers

PMID: 19122334
DOI: 10.2133/dmpk.23.406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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