Article
Polymorphisms and linkage disequilibrium of the OATP8 (OATP1B3) gene in Japanese subjects.
Drug metabolism and pharmacokinetics - 1 Apr 2006
Tsujimoto Masayuki, Hirata Sumio, Dan Yukihiko, Ohtani Hisakazu, Sawada Yasufumi
Abstract excerpt
OATP8, a member of the organic anion-transporting polypeptide family, is expressed on the sinusoidal membrane of hepatocytes, and transports endogenous organic anions, such as 17beta-glucuronosyl estradiol, and xenobiotic substances, such as digoxin. The objective of this study is to search for polymorphisms of the OATP8 gene and to assess the allele frequency of the polymorphisms in the Japanese population....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
