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Article

Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells.

Experimental cell research - 10 Sept 2007

D'Souza Theresa, Indig Fred E, Morin Patrice J

Abstract excerpt

Claudin proteins belong to a large family of transmembrane proteins essential to the formation and maintenance of tight junctions (TJs). In ovarian cancer, TJ protein claudin-4 is frequently overexpressed and may have roles in survival and invasion, but the molecular mechanisms underlying its regulation are poorly understood. In this report, we show that claudin-4 can be phosphorylated by protein kinase C (PKC)...

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Identifiers

PMID: 17678893
DOI: 10.1016/j.yexcr.2007.06.026
PMCID: PMC2034282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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