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Article

Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes.

The Biochemical journal - 15 Jun 2004

Baum Sonja, Bittins Margarethe, Frey Steffen, Seedorf Matthias

Abstract excerpt

Scp160p interacts in an mRNA-dependent manner with translating ribosomes via multiple RNA-binding heterogeneous nuclear ribonucleoprotein K-homology (KH) domains. In the present study, we show by protein-protein cross-linking that Scp160p is in close proximity to translation elongation factor 1A and the WD40 (Trp-Asp 40)-repeat containing protein Asc1p at ribosomes. Analysis of a truncation mutant revealed that...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15012629
DOI: 10.1042/BJ20031962
PMCID: PMC1224212

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Asc1p, a WD40-domain containing adaptor protein, is required for the interaction of the RNA-binding protein Scp160p with polysomes.PMID 15012629Read ↗

Direct link between RACK1 function and localization at the ribosome in vivo.Semantic proximity Read ↗

Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression.Semantic proximity Read ↗

The RNA-Binding Protein Scp160p Facilitates Aggregation of Many Endogenous Q/N-Rich Proteins.Semantic proximity Read ↗

Asc1p/RACK1 Connects Ribosomes to Eukaryotic Phosphosignaling.Semantic proximity Read ↗

Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast.Semantic proximity Read ↗

The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation.Semantic proximity Read ↗

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