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Article

Genetic influence of PTPN22 R620W polymorphism in tuberculosis.

Human immunology - 1 Dec 2005

Gomez Luis M, Anaya Juan-Manuel, Martin Javier

Abstract excerpt

The PTPN22 gene codes for an intracellular lymphoid-specific phosphatase (Lyp) that has a negative regulatory effect on T-cell activation. Because Lyp is an important molecule involved in the inflammatory response, and its levels are increased in cells that participate in the immune response against Mycobacterium tuberculosis, we hypothesized that the functional PTPN22 C1858T polymorphism could be a genetic...

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Source

Identifiers

PMID: 16690411
DOI: 10.1016/j.humimm.2005.11.008

Genes

PTPN22
TST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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