Article
Imprinting of tumor-suppressor genes in human placenta.
Epigenetics - 1 Jan 2009
Guilleret Isabelle, Osterheld Maria-Chiara, Braunschweig Richard, Gastineau Véronique, Taillens Suzanne, Benhattar Jean
Abstract excerpt
Transcriptional deregulation in cancer has been shown to be associated with epigenetic alterations, in particular to tumor-suppressor- gene (TSG) promoters. In contrast, DNA methylation of TSGs is not considered to be present in normal differentiated cells. Nevertheless, we previously showed that the promoter of the tumor-suppressor gene APC is methylated, for one allele only, in normal gastric cells. Recently,...
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