Article
Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals.
Journal of human genetics - 1 Jan 2002
Yamada Yoshiji, Fujisawa Michiko, Ando Fujiko, Niino Naoakira, Tanaka Masashi, Shimokata Hiroshi
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) is an important regulator of blood pressure (BP) and vascular remodeling, and thus may contribute to the pathogenesis of hypertension. A T-->C transition at nucleotide 869 of the TGF-beta1 gene results in a Leu-->Pro substitution at amino acid 10 of the signal peptide. We have now examined the possible association of the 869T-->C polymorphism of the TGF-beta1 gene with...
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