Article
Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication.
The Journal of biological chemistry - 20 Feb 2009
Wu Chia-Hsin, Yeh Shiou-Hwei, Tsay Yeou-Guang, Shieh Ya-Hsiung, Kao Chuan-Liang, Chen Yen-Shun, Wang Sheng-Han, Kuo Ti-Jung, Chen Ding-Shinn, Chen Pei-Jer
Abstract excerpt
Coronavirus (CoV) nucleocapsid (N) protein is a highly phosphorylated protein required for viral replication, but whether its phosphorylation and the related kinases are involved in the viral life cycle is unknown. We found the severe acute respiratory syndrome CoV N protein to be an appropriate system to address this issue. Using high resolution PAGE analysis, this protein could be separated into phosphorylated...
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