Article
Phosphorylation mutants of JC virus agnoprotein are unable to sustain the viral infection cycle.
Journal of virology - 1 Apr 2006
Sariyer Ilker K, Akan Ilhan, Palermo Victoria, Gordon Jennifer, Khalili Kamel, Safak Mahmut
Abstract excerpt
Many eukaryotic and viral regulatory proteins are known to undergo posttranslational modifications including phosphorylation, which plays a critical role in many aspects of cell function. Previous studies from our and other laboratories indicated that the JC virus (JCV) late regulatory protein, agnoprotein, plays an important role in the JCV life cycle. Agnoprotein contains several potential phosphorylation...
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