Article
Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.
Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008
Maga Giovanni, Crespan Emmanuele, Wimmer Ursula, van Loon Barbara, Amoroso Alessandra, Mondello Chiara, Belgiovine Cristina, Ferrari Elena, Locatelli Giada, Villani Giuseppe, Hübscher Ulrich
Abstract excerpt
The adenine misincorporated by replicative DNA polymerases (pols) opposite 7,8-dihydro-8-oxoguanine (8-oxo-G) is removed by a specific glycosylase, leaving the lesion on the DNA. Subsequent incorporation of C opposite 8-oxo-G on the resulting 1-nt gapped DNA is essential for the removal of the 8-oxo-G to prevent G-C to T-A transversion mutations. By using model DNA templates, purified DNA pols beta and lambda and...
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