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Article

Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda.

Nucleic acids research - 1 Jan 2006

Maga Giovanni, Shevelev Igor, Villani Giuseppe, Spadari Silvio, Hübscher Ulrich

Abstract excerpt

DNA polymerase lambda (pol lambda) is a member of the X family DNA polymerases and is endowed with multiple enzymatic activities. In this work we investigated the in vitro miscoding properties of full-length, human pol lambda either in the absence or in the presence of the human auxiliary proteins proliferating cell nuclear antigen (PCNA) and replication protein A (RP-A). Our data suggested that (i) pol lambda...

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Identifiers

PMID: 16522650
DOI: 10.1093/nar/gkl032
PMCID: PMC1390690

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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