Article
Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2009
Chang Nai-Wen, Chen Fei-Na, Wu Chen-Teng, Lin Chin-Fen, Chen Dar-Ren
Abstract excerpt
BACKGROUND: Apolipoprotein E4 (APOE4) allele is an important risk factor for breast cancer and affects clearance of chylomicron remnants. Tamoxifen therapy increases serum triglyceride levels and sometimes inducing severe hypertriglyceridemia in breast cancer patients. METHODS: Thirty-three women with breast cancer were recruited to examine the APOE polymorphism and fasting plasma lipid profiles before and after...
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