Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene.

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Article

Estrogen replacement therapy, serum lipids, and polymorphism of the apolipoprotein E gene.

Clinical chemistry - 1 Aug 1999

Garry P J, Baumgartner R N, Brodie S G, Montoya G D, Liang H C, Lindeman R D, Williams T M

Abstract excerpt

BACKGROUND: Pharmacogenomics, the study of genetic loci that modulate drug responsiveness, may help to explain why estrogen replacement therapy (ERT) has differential effects on serum lipid and lipoprotein concentrations in postmenopausal women who inherit distinct alleles of the apolipoprotein E gene (APOE). METHODS: We compared total-cholesterol, triglyceride, and lipoprotein (LDL and HDL) concentrations in 66...

Topics

Aged
Apolipoproteins E
Estrogen Replacement Therapy
Female
Genotype
Humans
Lipids
Male
Polymorphism, Genetic
Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 10430787

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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