Article
Need for reassessment of reported CYP2C19 allele frequencies in various populations in view of CYP2C19*17 discovery: the case of Greece.
Pharmacogenomics - 1 Jan 2009
Ragia Georgia, Arvanitidis Kostas I, Tavridou Anna, Manolopoulos Vangelis G
Abstract excerpt
INTRODUCTION: CYP2C19*17 is a novel variant allele causing ultrarapid metabolism of CYP2C19 substrates. In the present study we investigated the CYP2C19*17 allelic frequency and recalculated previously reported frequencies of the CYP2C19*1/*1 genotype and of all genotype-derived phenotypes for CYP2C19 in the Greek population. MATERIALS & METHODS: A total of 283 nonrelated healthy Greek ethnic subjects that had...
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