Article
Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.
Scandinavian journal of gastroenterology - 1 Jan 2009
Tahara Tomomitsu, Shibata Tomoyuki, Wang Fangyu, Nakamura Masakatsu, Okubo Masaaki, Yoshioka Daisuke, Sakata Mikijyu, Nakano Hiroshi, Hirata Ichiro, Arisawa Tomiyasu
Abstract excerpt
OBJECTIVE: Superoxide has been implicated in the pathogenesis of Helicobacter pylori-related diseases through inflammation. NADPH oxidase, a major source of superoxide generation, plays a critical role in H. pylori-related gastric inflammation. The aim of this study was to clarify the effect of the p22PHOX C242T polymorphism, an essential component of NADPH oxidase in the risk of gastroduodenal diseases, on the...
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