Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional role of the KLF6 tumour suppressor gene in gastric cancer.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2009

Sangodkar Jaya, Shi Jiayan, DiFeo Analisa, Schwartz Rachel, Bromberg Romina, Choudhri Aisha, McClinch Kim, Hatami Raheleh, Scheer Elias, Kremer-Tal Sigal, Martignetti John A, Hui Alex, Leung W K, Friedman Scott L, Narla Goutham

Abstract excerpt

Gastric cancer is the second most common cancer and a leading cause of cancer-related death worldwide. The Kruppel-like factor 6 (KLF6) tumour suppressor gene had been previously shown to be inactivated in a number of human cancers through loss of heterozygosity (LOH), somatic mutation, decreased expression and increased alternative splicing into a dominant negative oncogenic splice variant, KLF6-SV1. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Genes, Tumor Suppressor

Share to Kruppel-Like Transcription Factors

Share to Loss of Heterozygosity

Share to Neoplasm Transplantation

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 19101139
DOI: 10.1016/j.ejca.2008.11.009
PMCID: PMC2970616

Genes

KLF6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional role of the KLF6 tumour suppressor gene in gastric cancer.PMID 19101139Read ↗

Genetic alterations of the KLF6 gene in gastric cancer.Semantic proximity Read ↗

KLF6 IVS1 -27G/A polymorphism with susceptibility to gastric cancers in Korean.Semantic proximity Read ↗

Krüppel-Like Factor 7 is a Marker of Aggressive Gastric Cancer and Poor PrognosisSemantic proximity Read ↗

Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer☆Semantic proximity Read ↗

Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas.Semantic proximity Read ↗

Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.Semantic proximity Read ↗

The Krüppel-like factor 6 genotype is associated with gastric cancer in a Chinese population.Semantic proximity Read ↗

Clinicopathologic and Biological Significance of Kallikrein 6 Overexpression in Human Gastric CancerSemantic proximity Read ↗

Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.Semantic proximity Read ↗

A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.Semantic proximity Read ↗

Deletion, mutation, and loss of expression of KLF6 in human prostate cancer.Semantic proximity Read ↗

A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.