Article
Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytes.
Immunogenetics - 1 Jan 1991
Livingstone A M, Powis S J, Günther E, Cramer D V, Howard J C, Butcher G W
Abstract excerpt
Two alleles at the major histocompatibility complex (MHC)-linked locus cim determine "gain and loss" changes in the rat RT1.Aa class I molecule which affect its structure both as an alloantigen and as a restriction element. Alleles at the cim locus also influence the post-translational modification of RT1.Aa. These effects may reflect the participation of the cim gene product in the processes of peptide loading...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Chromosome Mapping
- Genes, MHC Class II
- Haplotypes
- Histocompatibility Antigens Class I
- Rats
- Recombination, Genetic
- T-Lymphocytes, Cytotoxic