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Article

Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1.

Molecular and cellular biology - 1 Apr 2007

Dasgupta Arindam, Sprouse Rebekka O, French Sarah, Aprikian Pavel, Hontz Robert, Juedes Sarah A, Smith Jeffrey S, Beyer Ann L, Auble David T

Abstract excerpt

Mot1 is an essential, conserved, TATA-binding protein (TBP)-associated factor in Saccharomyces cerevisiae with well-established roles in the global control of RNA polymerase II (Pol II) transcription. Previous results have suggested that Mot1 functions exclusively in Pol II transcription, but here we report a novel role for Mot1 in regulating transcription by RNA polymerase I (Pol I). In vivo, Mot1 is associated...

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Identifiers

PMID: 17296733
DOI: 10.1128/MCB.00054-07
PMCID: PMC1899949

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of rRNA synthesis by TATA-binding protein-associated factor Mot1.PMID 17296733Read ↗

Genome-wide transcriptional dependence on conserved regions of Mot1.Semantic proximity Read ↗

TATA-binding protein variants that bypass the requirement for Mot1 in vivo.Semantic proximity Read ↗

Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA.Semantic proximity Read ↗

Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae.Semantic proximity Read ↗

Enhancement of TBP binding by activators and general transcription factors.Semantic proximity Read ↗

Transcriptional corepression in vitro: a Mot1p-associated form of TATA-binding protein is required for repression by Leu3p.Semantic proximity Read ↗

Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II.Semantic proximity Read ↗

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters.Semantic proximity Read ↗

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.Semantic proximity Read ↗

RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing.Semantic proximity Read ↗

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