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Article

Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

1 Jan 2012

Abstract excerpt

Prostate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is...

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PMID: 24052720
DOI: 10.2478/v10034-012-0005-z

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