Article
Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients.
Molecular medicine reports - 1 May 2012
Xia Yanjie, Che Yena, Zhang Xinlin, Zhang Chengwei, Cao Yunxia, Wang Wenjun, Xu Pei, Wu Xiaoke, Yi Long, Gao Qian, Wang Yong
Abstract excerpt
Human androgen receptor (AR) contains a highly polymorphic polyglutamine tract encoded by CAG repeats [(CAG)n] in exon 1 of the AR gene. The CAG repeats, ranging from 11 to 38, have been reported to be inversely correlated with AR activity. A case-control study involving 261 polycystic ovary syndrome (PCOS) patients and 278 healthy controls was conducted. Fluorescently labeled DNA fragments containing (CAG)n were...
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