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Article

A dual-signal regulatory circuit activates transcription of a set of divergent operons in Salmonella typhimurium.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2008

Zhao Guang, Weatherspoon Natasha, Kong Wei, Curtiss Roy, Shi Yixin

Abstract excerpt

We present a molecular mechanism for signal transduction that activates transcription of the SlyA regulon in Salmonella typhimurium. We demonstrate that SlyA mediates transcriptional activation in response to guanosine tetraphosphate, ppGpp, according to the following observations: (i) in vivo transcription of SlyA-dependent genes is repressed when ppGpp is absent; this transcription can be restored by...

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Share to Chromosomes, Bacterial
Share to DNA, Intergenic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanosine Tetraphosphate

Share to Operon

Share to Protein Structure, Tertiary

Share to Quantitative Trait Loci

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Share to Transcription, Genetic

Source

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Identifiers

PMID: 19091955
DOI: 10.1073/pnas.0807071106
PMCID: PMC2634881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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