Article
Coordinated regulation of virulence during systemic infection of Salmonella enterica serovar Typhimurium.
PLoS pathogens - 1 Feb 2009
Yoon Hyunjin, McDermott Jason E, Porwollik Steffen, McClelland Michael, Heffron Fred
Abstract excerpt
To cause a systemic infection, Salmonella must respond to many environmental cues during mouse infection and express specific subsets of genes in a temporal and spatial manner, but the regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated into coordinated action, we constructed in-frame non-polar deletions of 83 regulators inferred to play a role in...
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