Article
G protein inactive and active forms investigated by simulation methods.
Proteins - 1 Jun 2009
Khafizov Kamil, Lattanzi Gianluca, Carloni Paolo
Abstract excerpt
Molecular dynamics and computational alanine scanning techniques have been used to investigate G proteins in their inactive state (the Galpha(i1)beta(1)gamma(2) heterotrimer) as well as in their empty and monomeric active states (Galpha(i1) subunit). We find that: (i) the residue Q204 of Galpha(i...
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