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Article

Mutant α-synuclein-induced degeneration is reduced by <i>parkin </i>in a fly model of Parkinson's disease

1 May 2006

Abstract excerpt

Parkinson's disease (PD) patients show a characteristic loss of motor control caused by the degeneration of dopaminergic neurons. Mutations in the genes that encode alpha-synuclein and parkin have been linked to inherited forms of this disease. The parkin protein functions as a ubiquitin ligase that targets proteins for degradation. Expression of isoforms of human alpha-synuclein in the Drosophila melanogaster...

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PMID: 16767175
DOI: 10.1139/g06-011

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