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Article

Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.

Human molecular genetics - 1 Mar 2009

Tateno Minako, Kato Shinsuke, Sakurai Takashi, Nukina Nobuyuki, Takahashi Ryosuke, Araki Toshiyuki

Abstract excerpt

Mutations in the superoxide dismutase 1 (sod1) gene cause familial amyotrophic lateral sclerosis (FALS), likely due to the toxic properties of misfolded mutant SOD1 protein. Here we demonstrated that, starting from the pre-onset stage of FALS, misfolded SOD1 species associates specifically with kinesin-associated protein 3 (KAP3) in the ventral white matter of SOD1(G93A)-transgenic mouse spinal cord. KAP3 is a...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19088126
DOI: 10.1093/hmg/ddn422
PMCID: PMC2640210

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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