Article
Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.
Journal of the National Cancer Institute - 2 Dec 1992
Jacobs I J, Kohler M F, Wiseman R W, Marks J R, Whitaker R, Kerns B A, Humphrey P, Berchuck A, Ponder B A, Bast R C
Abstract excerpt
BACKGROUND: It has been suggested that multiple sites of epithelial ovarian carcinoma on the peritoneal surface reflect polyclonal disease arising from multiple primary tumors in the peritoneal mesothelium, rather than monoclonal disease spread by metastases from one primary ovarian cancer. PURPO...
Topics
- Alleles
- Carcinoma
- Clone Cells
- DNA, Neoplasm
- Dosage Compensation, Genetic
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Heterozygote
- Humans
- Mutation
- Ovarian Neoplasms